Analysis of GPIIb/IIIa receptor number by quantification of 7E3 binding to human platelets
نویسندگان
چکیده
منابع مشابه
Analysis of GPIIb/IIIa receptor number by quantification of 7E3 binding to human platelets.
A large number of glycoprotein (GP) IIb/IIIa receptors are present on the surface of platelets. Studies to define precisely the number of GPIIb/IIIa receptors using specific monoclonal antibodies (MoAbs) or fibrinogen binding have, however, yielded varying estimates of receptor number. To refine the quantitative estimation of GPIIb/IIIa receptors on resting platelets, we have used the MoAb 7E3,...
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Fibrinogen Binding to Human Platelets*
Platelet-activating factor 1-0-alkyl-2-acetyl-englycero-3-phosphocholine (PAF-acether) triggers exposure of fibrinogen binding sites on platelets via binding to specific receptors. Comparison of 13H]PAFacether binding with lZ8I-fibrinogen binding shows that the rate with which PAF-acether binds to a number of receptors and not the degree of receptor occupancy determines how much fibrinogen bin...
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ژورنال
عنوان ژورنال: Blood
سال: 1996
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v88.3.907.bloodjournal883907